The Conrad Weiser Area School District is located in western Berks County in the U.S. state of Pennsylvania. This district serves South Heidelberg Township, Heidelberg Township, North Heidelberg Township and Marion Township and the Boroughs of Wernersville, Robesonia and Womelsdorf. Eight properties in a housing development in West Cocalico in Lancaster County also attend the District's schools. The District encompasses approximately 100 square miles (260 km2). According to 2000 federal census data, it serves a resident population of 23,777. By 2010, the District's population declined to 19,303 people. In 2009, Conrad Weiser Area School District residents’ per capita income was $22,732, while the median family income was $57,488. In the Commonwealth, the median family income was $49,501 and the United States median family income was $49,445, in 2010. According to Conrad Weiser Area School District officials, in school year 2007-08 the Conrad Weiser Area School District provided basic educational services to 3,026 pupils through the employment of 237 teachers, 176 full-time and part-time support personnel, and 18 administrators. Conrad Weiser Area School District received more than $10.4 million in state funding in school year 2007-08.

In the 1980s, a small group of Lancaster County property owners in the Cocalico School District were successful in seceding from the district. They formed a small district called Squire Hill Independent School District. The new District was short lived merging with Conrad Weiser Area School District.

Conrad Weiser Area School District operates four schools: Conrad Weiser High School (9th–12th), Conrad Weiser Middle School (5th–8th), Conrad Weiser East Elementary School (K-4th) and Conrad Weiser West Elementary School (K-4th).

The District is named for Conrad Weiser, an important Pennsylvanian in colonial days, especially known as an interpreter and emissary in councils between Native Americans and the colonies, especially Pennsylvania.